Optimization of Enzymatic Synthesis of D-Glucose-Based Surfactants Using Supported Aspergillus niger Lipase as Biocatalyst

Surfactants are amphiphilic molecules with the ability to modify surface tension between two surfaces. They can be obtained by various methods, main one being synthetic, from petroleum-based substrates. Their universal use in a wide range of fields has created global market and, consequently, ecological, and economic expectations for their production. Biocatalyzed processes, involving enzymes, address this objective processes complying principles green chemistry: energy saving, product selectivity, monodispersity, reduction solvents, eco-efficiency. For example, fatty-acid carbohydrate esters biobased surfactants that synthesized lipases. In work, we were interested synthesis D-glucose lauric ester, which presents interesting properties described literature, Aspergillus niger lipase, rarely sugar We optimized different parameters reaction media. This lipase appeared highly selective 6-O-lauroyl-D-glucopyranose. However, addition DMSO (dimethyl sulfoxide) as co-solvent displays duality, increasing yields but leading loss selectivity. addition, generates more complex energy-intensive purification processing steps. Consequently, bio-sourced alternative 2MeTHF3one (2-methyltetrahydrofuran-3-one) is proposed replace widely literature.